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KMID : 0357920110450030315
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Korean Journal of Pathology
2011 Volume.45 No. 3 p.315 ~ p.318
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Solitary Fibrous Tumor of the Conjunctiva with Heretofore Undescribed Pathologic Findings
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Kim Na-Rae
Ro Jae Y.
Shin Kyung-Hwan
Paik Hae-Jung
An Jung-Suk
Ha Seung-Yeon
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Abstract
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A 37-year-old female presented with a conjunctival mass discovered 3 years prior. An excisional biopsy revealed a patternless proliferation of round and spindle-shaped cells with an eosinophilic fibrillary cytoplasm and vesicular nuclei with occasional inclusions. Psammoma bodies were arranged around the dilated irregularly-shaped vessels. Differential diagnoses included conjunctival solitary fibrous tumor (SFT), nevus, glomangioma, ectopic meningioma, and mesectodermal leiomyoma. The tumor cells were immunoreactive for CD34, CD99, bcl-2 and vimentin, and were negative for smooth muscle actin, desmin, glial fibrillary acidic protein, S-100 protein, epithelial membrane antigen, and human melanoma black-45. Ultrastructurally, the tumor cells had rough endoplasmic reticulum, free ribosomes, and scattered mitochondria without basal lamina or cellular junctions, which are features of fibroblasts. A diagnosis of SFT was rendered based on the light microscopic, immunohistochemical, and electron microscopic findings. We report here on the second case of a SFT arising in the conjunctiva, which clinically and histologically mimics conjunctival nevus, glomangioma, ectopic meningioma, and a hybrid neurogenic-myogenic tumor such as mesectodermal leiomyoma.
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KEYWORD
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Solitary fibrous tumors, Conjunctiva, Antigens, CD34, CD99, Bcl-2
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